ARFIP2

ARFIP2
Mövcud strukturlar
PDB	Ortoloq axtarışı: PDBe RCSB
PDB id kodlarının siyahısı
	1I49, 1I4D, 1I4L, 1I4T, 4DCN
Tanımlayıcılar
Digər adları	ARFIP2, POR1, ADP ribosylation factor interacting protein 2
Xarici ID-lər	OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Genin yeri (İnsan)
Xromosom	Xromosom 11 (insan)
Son	6,481,479 bp
Genin yeri (Siçan)
Xromosom	Xromosom 7 (siçan)
Son	105,289,623 bp
RNT ifadəsi
	İfadə məlumatı üçün daha çox istinad
Gen ontologiyası
Molekulyar funksiya	• phosphatidylinositol-4-phosphate binding; • protein domain specific binding; • GO:0001948, GO:0016582 protein binding; • GTP binding; • identical protein binding; • cadherin binding; • GTP-dependent protein binding; • phospholipid binding;
Hücrəsəl komponent	• cell cortex; • trans-Golgi network membrane; • Membran; • ruffle; • cytosol; • Sitoplazma;
Bioloji proses	• ruffle organization; • small GTPase mediated signal transduction; • actin cytoskeleton organization; • regulation of Arp2/3 complex-mediated actin nucleation; • lamellipodium assembly; • intracellular protein transport;
	Sources:Amigo / QuickGO
Ortoloqlar
	23647
	76932
	ENSG00000132254
	ENSMUSG00000030881
	P53365
	Q8K221
	NM_001242854; NM_001242855; NM_001242856; NM_012402
	NM_029802
NP_001229783; NP_001229784; NP_001229785; NP_036534; NP_001357335;
	NP_001357337; NP_001357338; NP_001357340; NP_001357341; NP_001357342; NP_001363487; NP_001363488; NP_001363489; NP_001363490; NP_001363491; NP_001363492; NP_001363493
	NP_084078
	Wikidata
İnsanı göstər/ et	Siçanı göstər/ et

ARFIP2 və ya Arfaptin-2 — insanlarda ARFIP2 geni ilə kodlanan bir zülal.^[5]^[6]^[7]

Qarşılıqlı əlaqələri

ARFIP2-nin qarşılıqlı əlaqələri

Arf6^[8]^[9]
ARF3^[6]
ARF5^[6]^[9] və
RAC1^[5]^[9]^[10]

İstinadlar

↑ ¹ ² ³ GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
↑ ¹ ² ³ GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ ¹ ² Van Aelst L, Joneson T, Bar-Sagi D. "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). August 1996: 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
↑ ¹ ² ³ Kanoh H, Williger BT, Exton JH. "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). February 1997: 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
↑ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 2010-12-05 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-21.
↑ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
↑ ¹ ² ³ Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
↑ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ. "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). May 2001: 215–9. doi:10.1038/35075620. PMID 11346801.

Ədəbiyyatı

D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ. "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). May 2001: 215–9. doi:10.1038/35075620. PMID 11346801.
Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C. "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3). March 2002: 240–5. doi:10.1038/ncb761. PMID 11854752.
Lu L, Hong W. "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9). September 2003: 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S. "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23). June 2005: 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). October 2005: 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

[refGRCh38Ensembl-1] ¹ ² ³ GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017

[refGRCm38Ensembl-2] ¹ ² ³ GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8670882-5] ¹ ² Van Aelst L, Joneson T, Bar-Sagi D. "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). August 1996: 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.

[pmid9038142-6] ¹ ² ³ Kanoh H, Williger BT, Exton JH. "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). February 1997: 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.

[entrez-7] "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 2010-12-05 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-21.

[pmid9312003-8] D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.

[pmid11478794-9] ¹ ² ³ Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.

[pmid11346801-10] Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ. "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). May 2001: 215–9. doi:10.1038/35075620. PMID 11346801.

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