ARF6

ARF6
Mövcud strukturlar
PDB	Ortoloq axtarışı: PDBe RCSB
PDB id kodlarının siyahısı
	1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Tanımlayıcılar
Digər adları	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
Xarici ID-lər	OMIM: 600464 MGI: 99435 HomoloGene: 1256 GeneCards: ARF6
Genin yeri (İnsan)
Xromosom	Xromosom 14 (insan)
Son	49,897,054 bp
Genin yeri (Siçan)
Xromosom	Xromosom 12 (siçan)
Son	69,420,557 bp
RNT ifadəsi
	; ;
	İfadə məlumatı üçün daha çox istinad
Gen ontologiyası
Molekulyar funksiya	• nucleotide binding; • protein N-terminus binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • thioesterase binding;
Hücrəsəl komponent	• Sitoplazma; • recycling endosome; • endosome; • Holci kompleksi; • cell projection; • membrane; • focal adhesion; • ruffle; • myelin sheath; • Membran; • endocytic vesicle; • intracellular anatomical structure; • cell cortex; • early endosome; • endosome membrane; • extracellular exosome; • filopodium membrane; • recycling endosome membrane; • cleavage furrow; • cytosol; • Flemming body; • early endosome membrane; • presynapse; • glutamatergic synapse;
Bioloji proses	• establishment of epithelial cell polarity; • cell differentiation; • regulation of filopodium assembly; • positive regulation of actin filament polymerization; • ruffle organization; • small GTPase mediated signal transduction; • regulation of Rac protein signal transduction; • nervous system development; • negative regulation of dendrite development; • Hüceyrənin bölünməsi; • negative regulation of receptor-mediated endocytosis; • cell adhesion; • protein localization to cell surface; • protein transport; • protein localization to endosome; • cell cycle; • liver development; • myeloid cell apoptotic process; • GO:0033109 cortical actin cytoskeleton organization; • vesicle-mediated transport; • regulation of dendritic spine development; • hepatocyte apoptotic process; • GO:0015915 transport; • positive regulation of protein localization to plasma membrane; • intracellular protein transport; • regulation of neuron projection development; • endocytic recycling; • synaptic vesicle endocytosis; • positive regulation of keratinocyte migration; • ruffle assembly; • maintenance of postsynaptic density structure; • positive regulation of adherens junction organization; • regulation of presynapse assembly; • cellular response to nerve growth factor stimulus; • negative regulation of protein localization to cell surface; • positive regulation of protein secretion; • positive regulation of protein homodimerization activity;
	Sources:Amigo / QuickGO
Ortoloqlar
	382
	11845
	ENSG00000165527
	ENSMUSG00000044147
	P62330
	P62331
	NM_001663
	NM_007481
	NP_001654
	NP_031507
	Wikidata
İnsanı göstər/ et	Siçanı göstər/ et

ARF6 — (ing. ADP ribosylation factor 6) 14-cü xromosomun qısa qolunda insanlarda tapılan tək gen tərəfindən kodlanmış zülal.^[5] Zülalın polipeptid zəncirinin uzunluğu 175 amin turşusu, molekulyar çəkisi isə 20.082-dir.

ARF6 çox vaxt bioloji membranların və transmembran protein yüklərinin daşınmasında iştirak edən çoxlu hüceyrə funksiyalarına malikdir. ARF6 xüsusi olaraq plazma membranı zülallarının endositozunda və həmçinin daha az dərəcədə plazma membranı zülallarının təkrar emalında iştirak edir.

Funksiyası

Bu gen, Ras super ailəsinin^[6] bir hissəsi olan insan ARF gen ailəsinin bir üzvünü kodlaşdırır.

ARF genləri vəba toksininin ADP-ribosiltransferaza fəaliyyətini stimullaşdıran və vezikulyar ticarətdə və fosfolipaz D-nin aktivatoru kimi rol oynayan kiçik guanin nukleotid bağlayan zülalları kodlayır. Bu genin məhsulu plazma membranında lokallaşdırılır və vezikulyar daşınma, membranın lipidlərinin yenidən qurulması və aktiniumun yenidən qurulmasına səbəb olan siqnal yollarını tənzimləyir. Bu genin psevdogeni 7-ci xromosomda yerləşir.^[7]

ARF6 reseptorların aktivləşdirilməsindən sonra βarrestin^[8] ilə qarşılıqlı təsir göstərə bilər.

Qarşılıqlı əlaqələri

ARF6-nın aşağıdakılarla qarşılıqlı əlaqədə olduğu göstərilmişdir:

Arrestin beta 1^[9]
ARFIP2^[10]^[11]
CHRM3^[12]
EXOC5^[13]
KIAA0090^[14]
Rac1^[15]

İstinadlar

↑ ¹ ² ³ GRCh38: Ensembl release 89: ENSG00000165527 - Ensembl, May 2017
↑ ¹ ² ³ GRCm38: Ensembl release 89: ENSMUSG00000044147 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "HUGO Gene Nomenclature Commitee, HGNC:659" (англ.). İstifadə tarixi: 11 вересня 2017.^{[ölü keçid]}
↑ [nhttps://en.wikipedia.org/wiki/Ras_superfamily "Arxivlənmiş surət"]. 2023-02-19 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
↑ "Entrez Gene: ARF6 ADP-ribosylation factor 6".
↑ "Arxivlənmiş surət". 2023-05-21 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
↑ Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45). November 2001: 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.
↑ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
↑ Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
↑ Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS. "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36). September 2003: 33818–30. doi:10.1074/jbc.M305825200. PMID 12799371.
↑ Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P. "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector". J. Cell Biol. 163 (5). December 2003: 1111–21. doi:10.1083/jcb.200305029. PMC 2173613. PMID 14662749.
↑ Prieto C, De Las Rivas J. "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue). July 2006: W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013. 2010-04-09 tarixində orijinalından arxivləşdirilib.
↑ Peru y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A. "Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B". J. Neurosci. 32 (49). December 2012: 17706–13. doi:10.1523/JNEUROSCI.1944-12.2012. PMC 3535434. PMID 23223291.

Ədəbiyyatı

Sabe H. "Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion". J. Biochem. 134 (4). 2004: 485–9. doi:10.1093/jb/mvg181. PMID 14607973.
Joseph AM, Kumar M, Mitra D. "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1). 2005: 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M. "Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells". J. Biol. Chem. 266 (5). 1991: 2772–7. doi:10.1016/S0021-9258(18)49913-9. PMID 1993656.
Stearns T, Willingham MC, Botstein D, Kahn RA. "ADP-ribosylation factor is functionally and physically associated with the Golgi complex". Proc. Natl. Acad. Sci. U.S.A. 87 (3). 1990: 1238–42. Bibcode:1990PNAS...87.1238S. doi:10.1073/pnas.87.3.1238. PMC 53446. PMID 2105501.
D'Souza-Schorey C, Stahl PD. "Myristoylation is required for the intracellular localization and endocytic function of ARF6". Exp. Cell Res. 221 (1). 1995: 153–9. doi:10.1006/excr.1995.1362. PMID 7589240.
D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. "A regulatory role for ARF6 in receptor-mediated endocytosis". Science. 267 (5201). 1995: 1175–8. Bibcode:1995Sci...267.1175D. doi:10.1126/science.7855600. PMID 7855600.
Welsh CF, Moss J, Vaughan M. "ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin". Mol. Cell. Biochem. 138 (1–2). 1995: 157–66. doi:10.1007/BF00928458. PMID 7898460.
Amor JC, Harrison DH, Kahn RA, Ringe D. "Structure of the human ADP-ribosylation factor 1 complexed with GDP". Nature. 372 (6507). 1995: 704–8. doi:10.1038/372704a0. PMID 7990966.
Orcl L, Palmer DJ, Amherdt M, Rothman JE. "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439). 1993: 732–4. Bibcode:1993Natur.364..732O. doi:10.1038/364732a0. PMID 8355790.
Helms JB, Palmer DJ, Rothman JE. "Two distinct populations of ARF bound to Golgi membranes". J. Cell Biol. 121 (4). 1993: 751–60. doi:10.1083/jcb.121.4.751. PMC 2119793. PMID 8491770.
Cavenagh MM, Whitney JA, Carroll K, Zhang Cj, Boman AL, Rosenwald AG, Mellman I, Kahn RA. "Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane". J. Biol. Chem. 271 (36). 1996: 21767–74. doi:10.1074/jbc.271.36.21767. PMID 8702973.
D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. 16 (17). 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
Frank S, Upender S, Hansen SH, Casanova JE. "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1). 1998: 23–7. doi:10.1074/jbc.273.1.23. PMID 9417041.
Yang CZ, Heimberg H, D'Souza-Schorey C, Mueckler MM, Stahl PD. "Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells". J. Biol. Chem. 273 (7). 1998: 4006–11. doi:10.1074/jbc.273.7.4006. PMID 9461590.
Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14). 1998: 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
Andreev J, Simon JP, Sabatini DD, Kam J, Plowman G, Randazzo PA, Schlessinger J. "Identification of a new Pyk2 target protein with Arf-GAP activity". Mol. Cell. Biol. 19 (3). 1999: 2338–50. doi:10.1128/MCB.19.3.2338. PMC 84026. PMID 10022920.
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG. "ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements". J. Cell Sci. 112 (6). 1999: 855–66. doi:10.1242/jcs.112.6.855. PMID 10036235.
Kim HS. "Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2). 1999: 94. doi:10.1159/000015225. PMID 10343114.
Langille SE, Patki V, Klarlund JK, Buxton JM, Holik JJ, Chawla A, Corvera S, Czech MP. "ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1". J. Biol. Chem. 274 (38). 1999: 27099–104. doi:10.1074/jbc.274.38.27099. PMID 10480924.
Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho Y. "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5). 1999: 521–32. doi:10.1016/S0092-8674(00)81540-8. PMID 10589680.
Ikeda S, Ushio-Fukai M, Zuo L, Tojo T, Dikalov S, Patrushev NA, Alexander RW. "Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis". Circ. Res. 96 (4). 2005: 467–75. doi:10.1161/01.RES.0000158286.51045.16. PMID 15692085.

[refGRCh38Ensembl-1] ¹ ² ³ GRCh38: Ensembl release 89: ENSG00000165527 - Ensembl, May 2017

[refGRCm38Ensembl-2] ¹ ² ³ GRCm38: Ensembl release 89: ENSMUSG00000044147 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[HGNC-5] "HUGO Gene Nomenclature Commitee, HGNC:659" (англ.). İstifadə tarixi: 11 вересня 2017.^{[ölü keçid]}

[6] [nhttps://en.wikipedia.org/wiki/Ras_superfamily "Arxivlənmiş surət"]. 2023-02-19 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.

[7] "Entrez Gene: ARF6 ADP-ribosylation factor 6".

[8] "Arxivlənmiş surət". 2023-05-21 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.

[pmid11533043-9] Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45). November 2001: 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.

[pmid9312003-10] D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.

[pmid11478794-11] Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.

[pmid12799371-12] Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS. "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36). September 2003: 33818–30. doi:10.1074/jbc.M305825200. PMID 12799371.

[pmid14662749-13] Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P. "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector". J. Cell Biol. 163 (5). December 2003: 1111–21. doi:10.1083/jcb.200305029. PMC 2173613. PMID 14662749.

[pmid16845013-14] Prieto C, De Las Rivas J. "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue). July 2006: W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013. 2010-04-09 tarixində orijinalından arxivləşdirilib.

[pmid23223291-15] Peru y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A. "Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B". J. Neurosci. 32 (49). December 2012: 17706–13. doi:10.1523/JNEUROSCI.1944-12.2012. PMC 3535434. PMID 23223291.

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